Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity. Hydrogen sulfide (H2S) treatment restored chromatin interactions and ...

A multi-institutional study has mapped the genetic circuitry that determines whether CD8 killer T cells become durable immune defenders or lapse into exhaustion, and has shown that disabling two ...

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...

Scientists uncover a new “recipe” that shows how exhausted T cells can be reprogrammed to regain their ability to attack tumors.

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study: ...

Meet the Jekyll and Hyde of the immune system: activated CD8⁺ T cells. On June 24 in Nature Immunology, researchers led by Dorian McGavern at the National Institutes of Health introduce a granzyme ...

Researchers at the University of Virginia School of Medicine have identified a specific enzyme inside immune cells that keeps Toxoplasma gondii, one of the most common brain parasites on the planet, ...

A parasite that may already be hiding in your brain has a shocking survival trick: it can infect the very immune cells sent ...

A new study identifies an extreme but effective way that brain immune cells can prevent the parasite Toxoplasma gondii from spreading: they kill themselves to eliminate the dangerous microbes they ...