Phospholipase A2 (PLA2) enzymes are known to play a role in many inflammatory diseases, including asthma, arthritis and atherosclerosis. It then stands to reason that PLA2 inhibitors could represent a ...

Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job. Now researchers at Chalmers University of Technology have developed a computer model ...

Mathematical modeling helps researchers to understand how enzymes in the body work to ensure normal functioning. The models also can show how genetic mutations alter the enzymes' behavior in ways that ...

Coupled oxygen transfer and electron transfer reactions that use cofactors are enzymatic reactions of crucial significance to all lifeforms from bacteria to vertebrates. In the European Journal of ...

Tiit Lukk, Ayano Sakai, Chakrapani Kalyanaraman, Shoshana D. Brown, Heidi J. Imker, Ling Song, Alexander A. Fedorov, Elena V. Fedorov, Rafael Toro, Brandan Hillerich, Ronald Seidel, Yury Patskovsky, ...

A team from the University of Illinois has developed a modeling framework connecting enzyme activity related to photosynthesis to yield. This is the first time a model has tied the dynamic ...

A newly discovered enzyme motif reveals how ocean microbes are evolving to digest plastic, potentially aiding future cleanup ...

Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and ...

The inhibition of an enzyme associated with neurodegeneration processes reduced the toxic effect of tau, one of the proteins that damage neurons in Alzheimer’s disease (AD). A group of scientists from ...

To better understand PLA2 enzymes and help drive therapeutic drug development, researchers developed 3-D computer models that show exactly how two PLA2 enzymes extract their substrates from cellular ...