New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...

This important study presents a thoughtful design and characterization of chimeric influenza hemagglutinin (HA) head domains combining elements of distinct receptor-binding sites. The results provide ...

Tiny viruses that only infect and kill bacteria can help treat deadly antibiotic-resistant bloodstream infections with ...

Researchers at Washington University School of Medicine in St. Louis have identified central routes that two deadly viruses take to invade human cells and have designed decoy molecules that block the ...

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource ...

A promising breakthrough in autoimmune disease research may open the door to safer and more effective treatments. Scientists ...

Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...

Interleukin 1 receptor accessory protein (IL1RAP) is a receptor that activates signaling pathways triggered by IL1α/β, IL33 and IL36α/β/γ, which are involved in several autoimmune or inflammatory ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, ...

Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform ...