The Federal Aviation Administration (FAA) and the National Transportation Safety Board (NTSB) will lead the investigation into the incident.

As the sun set and businesses started to close in Louisville, Kentucky, on Tuesday, the evening calm was suddenly shattered by a giant explosion near the city’s airport.

A UPS cargo plane crashed near Louisville’s Muhammad Ali International Airport, sparking a massive explosion and fire visible across the city. Multiple agencies are responding, with confirmed injuries and road closures as the investigation continues.

Video of the deadly crash showed flames on one of the plane's wings, and a huge fireball erupting as the aircraft hit the ground.