Arizona Cardinals face the Dallas Cowboys tonight. Quarterback Kyler Murray is questionable with a foot sprain. Jacoby Brissett will start the game. Murray is recovering and may have a role, but his return is not confirmed.

San Fransisco 49ers OC Klint Kubiak addressed the media on Thursday and discussed the injury status of QB Brock Purdy, offering a vague update.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from September 21, 2025 on ESPN.

“Head coach Kyle Shanahan confirmed Monday that defensive lineman Nick Bosa suffered a torn ACL in his right knee during Sunday's win over the Arizona Cardinals. Bosa will undergo season-ending surgery,” 49ers.com’s Briana Jeannel wrote.

At 2-5, the Arizona Cardinals face a tall and difficult task to turn things around, and, in predicting how it will end, it's too tall to conquer.

The San Francisco 49ers and Arizona Cardinals are set to kick off on Sunday, and they'll be without a few players, who have been deemed inactive.

The NFC West didn't see their Week 7 action end until late Monday night, as the Seattle Seahawks played the final game of the week against the Houston Texans. Nothing changed in the standings, as three of the teams won their games, while the Arizona Cardinals lost their fifth consecutive game and remained in last place.

The San Francisco 49ers finished their Week 7 contest with a 20-10 win over the Atlanta Falcons on "Sunday Night Football" at Levi's® Stadium.

The San Francisco 49ers have gotten out to a fairly improbable 2-0 start this season. The same can be said for their Week 3 opponent, the Arizona Cardinals. The players listed below will be ones to watch as both teams look to secure not just a 3-0 record ...