Background and objectives Emerging evidence implicates immune dysregulation and neuroinflammation in the pathogenesis of epilepsy, yet the causal mechanisms remain unclear. This study aimed to ...

The NEURL E3 ubiquitin ligases selectively activate the Notch ligands DLL1 and JAG1, but not DLL4 and JAG2. This differential ...

This important study presents a thoughtful design and characterization of chimeric influenza hemagglutinin (HA) head domains combining elements of distinct receptor-binding sites. The results provide ...

Tiny viruses that only infect and kill bacteria can help treat deadly antibiotic-resistant bloodstream infections with ...

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource ...

A promising breakthrough in autoimmune disease research may open the door to safer and more effective treatments. Scientists ...

Selective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby ...

Interleukin 1 receptor accessory protein (IL1RAP) is a receptor that activates signaling pathways triggered by IL1α/β, IL33 and IL36α/β/γ, which are involved in several autoimmune or inflammatory ...

Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, ...

Peroxisomes are essential cell organelles that play a vital role in lipid metabolism and cellular detoxification. To perform ...

VYVGART demonstrated clinically meaningful benefit across all AChR-Ab seronegative gMG subtypes in ADAPT SERON, supporting broad role of ...

Study sets stage for development of synthetic biosensors with custom-built sensing and responses for basic and translational cell engineering applications.