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  1. Patent foramen ovale - Symptoms & causes - Mayo Clinic

    Oct 25, 2022 · A patent foramen ovale (PFO) is a hole in the heart that didn't close the way it should after birth. The hole is a small flaplike opening between the upper heart chambers.

  2. Patent foramen ovale - UpToDate

    Aug 12, 2025 · Patent foramen ovale (PFO) is a congenital cardiac lesion that frequently persists into adulthood [1-3]. Although most patients with a PFO are asymptomatic, a variety of …

  3. Patent Foramen Ovale (PFO): Causes & Treatment - Cleveland Clinic

    Jul 10, 2025 · Patent foramen ovale is a hole between your heart’s upper chambers. They’re normal in babies under 3. But sometimes, they stay open past that and need treatment.

  4. Patent Foramen Ovale: symptoms, diagnosis, and complications - WebMD

    Aug 2, 2024 · A patent foramen ovale is an opening that some adults have between the top two chambers of their hearts. Everyone has this opening early in life, but it often seals during infancy.

  5. Patent Foramen Ovale (PFO) - NewYork-Presbyterian

    When the flap doesn’t fully close, it’s called a patent foramen ovale (PFO). This occurs in about one in four people, with the vast majority having no symptoms or medical problems.

  6. New insights about the risks from a "hole" in the heart

    May 1, 2025 · Known as a patent foramen ovale (PFO), this common anatomical variation only rarely causes any symptoms. Most people with a PFO never know they have it, and the …

  7. Patent Foramen Ovale (PFO) - American Heart Association

    Sep 26, 2023 · Patent foramen ovale (PFO) or hole in the heart, affects millions of people and can cause a stroke.

  8. Patent Foramen Ovale - Johns Hopkins Medicine

    A patent foramen ovale (PFO) is a small hole between the two upper chambers of the heart, the right and the left atrium. Normally, a wall separates these chambers. No blood can flow …

  9. Patent Foramen Ovale - StatPearls - NCBI Bookshelf

    Sep 12, 2022 · Patent foramen ovale (PFO) occurs when a remnant of normal fetal anatomy abnormally persists into adulthood. It represents a benign finding in the newborn periods.

  10. Patent foramen ovale - Penn Medicine

    Oct 23, 2023 · Definition Patent foramen ovale (PFO) is a hole between the left and right atria (upper chambers) of the heart. This hole exists in everyone before birth, but most often closes …